Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

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Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.Occasionally, cell bodies and photoreceptor inner fibers exhibited strong TNAP labeling (arrows on Fig. 6.2f). ... Here, TNAP activity appeared to be somewhat stronger than in the outer parts of the layer. TNAP staining pattern in the frog retina (data not shown) was similar to the other species in this subgroup. The IPL wasanbsp;...

Title:Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)
Author: Caroline Fonta, Laszlo Negyessy
Publisher:Springer - 2015-07-28

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